Fabrizio Manetti received the “Laurea” degree (summa cum laude) in Pharmaceutical Chemistry and Technology (Chimica e Tecnologia Farmaceutiche), and the Ph.D. in Medicinal Sciences from the University of Siena, Italy.
In 1997, he was a visiting scientist at the Glaxo-Wellcome (Verona, Italy) to work on a virtual screening project based on large databases of antibacterial molecular fingerprints.
A postdoctoral position was held between 1997 and 1998 at the Department of Chemistry (University of Rome "La Sapienza") within the project "Microbial production of native and recombinant tailor-made enzymes for fine chemicals production".
A postdoctoral position was held between 1998 and 1999, at the University of Siena, working on calcium channel entry blockers structurally related to diltiazem.
From 1999 to 2002, he had a position as "assegnista di ricerca" at the University of Siena working on the "Application of computational methodologies to the issues related to HIV-1 infection".
From 2002, he was an Assistant Professor at the University of Siena, working on different research areas in the field of medicinal chemistry (antitubercular compounds, hedgehog inhibitors, HIV-1 inhibitors, ATP-competitive tyrosine kinase inhibitors).
From 2015, he is an Associate Professor of Medicinal Chemistry at the University of Siena.
He is author or co-author of 145 papers and reviews in international journals (H-index 38, 3980 citations: Scopus, October 20, 2017), 13 international patents (concessions), and more than 60 posters and oral communications.
He regularly serves as a reviewer for several international scientific journals, such as Archiv der Pharmazie, Bioorganic & Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Carbohydrate Research, Cell & Tissue Research, Computational Biology and Chemistry, Current Molecular Pharmacology, European Journal of Medicinal Chemistry, European Journal of Pharmaceutical Sciences, Expert Opinion On Drug Discovery, Fundamental & Clinical Pharmacology, International Journal of Medicinal Chemistry, International Journal of Molecular Sciences, Journal of Chemical Information and Modeling, Journal of Enzyme Inhibition and Medicinal Chemistry, Journal of Functional Food, Journal of Medicinal Chemistry, Medicinal Chemistry Communications, Molecules, Nature Communications, Oncogene, Organic & Biomolecular Chemistry, Synthesis, Pest Management Science.
He served as a reviewer for: Programma SIR 2014 (MIUR); Fonds National de la Recherche, Luxembourg (CORE 2012); Futuro in Ricerca 2012 (MIUR); Nova Scotia Health Research Foundation 2011; IDEA Giovani Ricercatori Università di Bari 2009; PRIN 2007 (MIUR); VQR 2004-2010; VQR 2011-2014.
He held the courses: “Approcci computazionali alla progettazione dei farmaci”, “Elementi di statistica”, “Analisi dei Prodotti Dietetici”, “Biotecnologie Farmaceutiche”, “Metodologie Avanzate in Chimica Farmaceutica”, “Drug Discovery and Drug Development”, “Analisi dei Medicinali I”, “Didattica delle tecniche computazionali in chimica”, “Didattica di laboratorio delle tecniche computazionali in chimica”, “Fondamenti di Chimica Farmaceutica”.
From 2011, he hold the course “Analisi Chimico Farmaceutiche I”.