Fundamental concepts in drug absorption, distribution and elimination. Mechanism of drug action (classification of receptors and drug effects). The relationship between drug concentration and effect. Kinetics of drug and metabolites following drug administration. Pharmacokinetic parameters. Basic elements of the design and evaluation of therapeutic regimes. Causes of variability in human drug response. The adjustment of dosage based on age, weight and renal function, kinetics consequence of drug interactions. Present principles for the monitoring of drugs therapy. Pharmacogenetics and adverse drug reactions (ADR). Factors which affect therapeutic outcome: drug-drug interactions, genetic factors. Drugs prescription.
Chemotherapy of microbial, fungal, parasitic and neoplastic diseases. Antiviral and immunosuppressive agents.