Biopharmaceutics: Classification of dosage forms, Gastrointestinal transit, Drug absorption, Fick’s law, Absolute and Relative Bioavailability, Bioequivalence, Factors affecting bioavailability, Dissolution process, Noyes-Whitney equation, Factors affecting dissolution rate.
Preformulation: Physico-chemical characterization of drugs, pKa, Crystal habitus, Polymorphism, Thermal analysis, Electron microscopy, Solubility, Dissolution, LogP and LogD, Permeability, BCS classification of drugs, Drug stability.
Dosage Forms: Powders, Granules, Pellets, Capsules (Hard capsules and Soft gelatin capsules), Tablets, Dispersed systems (Solutions, Syrups, Parenteral drug delivery systems, Emulsions, Suspensions, Colloidal dispersions), Semisolid Dosage Forms (Ointments, Creams, Gels), Suppositories, Sustained and Controlled Drug Delivery Systems (Polymers used in drug delivery, Liposomes), Patches, Aerosols.
Packaging of pharmaceutical products: Packaging components, types, factors influencing choice of containers.
Basic unit operations in dosage form preparation: Dissolution, Filtration, Sterilization, Depyrogenation, Liophilyzation, Milling, Blending, Microencapsulation, Granulation, Compressing, Coating of tablets, Melting, Suspending, Emulsification.
Practical Pharmaceutical Technology. Powders, Solutions, Syrups, Emulsions, Suspensions, Ointments, Creams, Gels.
National Health Service
Introduction to pharmacoeconomy.
Introduction to pharmaceutical marketing.
International market of drugs.
The most important drug companies.
Italian pharmacopoeia (FU XII Ed), FU tables.
The ethic and the role of the Pharmacy Board.
The organization of the pharmacy system.
Classification of drugs, new drug applications, drug price.
Dispensing procedures: prescription and its parts, responding to prescription, calculation for compounding and dispensing, containers and closures for dispensed products, labeling of dispensed medicine, prescription pricing and record. SOP and OTC. Prescription types.
The regulation of the controlled substances.
Intellectual property protection.