INTRODUCTION. Aspects of chemical analysis in the pharmaceutical field. Types of analysis: classification and working ranges. Common techniques. Quantitative expressions of the concentration of a solution and other notes on fundamental theoretical principles of reactions in solution. Laboratory equipment : basic techniques and apparatus commonly used in analytical operations. The safety in the chemistry laboratory to prevent or minimize hazards, harmful exposures, and injuries. Errors and statistics: application of statistical procedures to the analytical results.
TITRIMETRIC ANALYSIS. Basic principles. Reactions and reagents in titrimetric analysis. Primary and secondary standards. Titration curves, factors which influence the evidence of the final point. Indicators. Titrating solutions and their standardisation. Precipitation titrations: Mohr, Volhard and Fajans titrations. Application: analysis of halides. Neutralisation titrations: titration curves of acids and bases. Complexation titrations: inorganic complexing agents, polycarboxylic acids. EDTA titrations: conditional formation constant, titration curves, types of titrations. Metallochromic indicators. Quantitative complexometric analysis. Redox titrations: oxidising and reducing agents. Nernst equation. Redox titration curves. Indicators. Calculation of equilibrium constant and potential at the endpoint. Permanganometry, iodimetry, iodometry.
LABORATORY PRACTICE. Neutralisation titrations. Precipitation titrations. Redox titrations. Complexometric titrations.