1. Federal and Regional States from the perspective of political devolution – 2. Self-government and administrative devolution. – 3. Unitary Principle, Indivisibility of Republic Principle, Autonomy Principle ex art. 5 Const. – 4. Linguistic Minorities Protection between art. 6 Const. and Special Statutes. – 5. Evolution and implementation of Italian regionalism from the Unification of Italy to Republican Constitution. – 6. The Reform of Title V , Part II, of Constitution: overall analysis. – 7. Regional form of government. – 8. Statutory Power. – 9. Regional electoral matter - 10. Regional Legislative Powers: the situation before the Reform; Special Statutes Regions and “most favourable clause”; concurrent legislative competence; residual legislative competence. – 11. Regional legislative powers between “cross matters”, “residual clause” and “subsidiarity calling-up”. – 12. Fair Cooperation Principle: from ruling n. 303/2003 to ruling n. 33/2011 of the Constitutional Court. – 13. Administrative Functions: subsidiarity, substitute powers and stringent conditions to exercise the “direct and coordination” State function. – 14. International and European Union Relationships of Italian Regions. – 15. Problematic aspects of the Italian Regionalism evolution towards a mainly “cooperative” pattern.