General principles of pharmacodynamics and pharmacokinetics. Current and innovative drugs for treating diseases affecting the autonomous- and central nervous- systems, the respiratory and gastric systems. Therapy for the treatment of pain, inflammatory- and autoimmune-based diseases. General anesthetics and local anesthetics. Cardiovascular function modulation. Hypertension therapy. Main cardiac pathologies: Heart failure, arrhythmias, myocardial ischemia, angina pectoris. Pharmacological therapy of dyslipidaemias and hypercholesterolaemia. Oral and Injectable anticoagulant drugs and role of genetic polymorphism in therapy with these drugs. Novel oral anticoagulants. Treatment of the main pathologies of the endocrine system. Pancreas and diabetes therapy. Endocrine control of reproduction. Immunosuppressant drugs. Antibiotic chemotherapy, general principles. Targets of chemotherapy drugs, main pathogens (bacteria and viruses), adverse effects of chemotherapy, determination of MIC and MBC. Time-dependent and concentration-dependent antibiotics. Combined chemotherapy and drug resistance. Antibiotics, Antifungals, Antivirals. Anticancer drugs. For each treated topic the implications in dentistry will be highlighted, also by reporting the data of recent scientific literature.